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Beverly Hofstadter, is a neuroscientist and world-renowned psychiatrist, his sister is a medical researcher, and his father, Dr. Also, his brother Michael is a Harvard law professor.

He is known to be lactose intolerant, and is also known for playing the cello.

He shared an apartment in Pasadena with colleague and friend Dr. Unlike his equally geeky friends, Leonard is interested and quite adept in building interpersonal and social relationships with other people.

Compared to his friends, he is relatively successful with women.

The two attempted a long-distance relationship after Priya moved back to India, but Leonard eventually broke up with her in season five after she admitted to cheating on him with her former boyfriend.