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In 2006, Parker received the Golden Globe Award for Best Actress – Television Series Musical or Comedy, given by the Hollywood Foreign Press Association, for her lead role in Weeds.In that category, she defeated the four leads of Desperate Housewives.Mary-Louise Parker (born August 2, 1964) is an American actress and author.

Following this, she returned to work on the fifth season of Weeds. In 2013, Parker was honored for her work with Hope North, an organization that works in the educating and healing of young victims in Uganda's civil war.

Parker took the lead role in the Roundabout Theatre Broadway revival of the play Hedda Gabler, running from January through March 29, 2009. The actress began her involvement with the organization after meeting a former victim of Uganda's civil war.

She dedicated the award to the late John Spencer, known for his work as Leo Mc Garry on The West Wing.

After receiving the award, Parker stated: "I'm really in favor of legalizing marijuana.

Among stage and independent film appearances thereafter, Parker received the Tony Award for Best Actress in a Play for her portrayal of Catherine Llewellyn in David Auburn's Proof in 2001, among other accolades.