Email: Copyright 2014 Scientific Academic Publishing. There are hydroxamates with reported anti-HIV activity such as the hydroxyurea which acts as inhibitors of cellular enzyme ribonucleoside diphosphate reductase. 1 Hydroxamates have high affinity for ferric ions that nature has evolved families of hydroxamic acids to function as no N-binding compounds siderophores in bacteria.
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Carbodiimides hydrolyze to form ureas, which makes them uncommon in nature. Hydroxyurea are also used for treatment of chronic myelogenal leukemia, myeloproliferative syndromes and sickle cell anemia. 2 Hydroxamates of amino acids are effective inhibitors of amino peptidases.
13 Hydroxamic acids are capable of inhibiting a variety of enzymes, including ureases, 14, 15 peroxidises 16, and matrix metalloproteinases.